Additional Ventures Research Grants 2027 | Up to US$600,000 for Single Ventricle Heart Disease Research
Additional Ventures Research Grants 2027 | Up to US$600,000 for Single Ventricle Heart Disease Research. Additional Ventures is offering research grants of up to US$600,000 through its Single Ventricle Research Fund (SVRF), supporting foundational research aimed at improving outcomes for people living with single ventricle heart disease.
The funding programme supports researchers investigating the mechanisms behind single ventricle heart disease and its long-term complications. It aims to advance scientific understanding, improve treatment approaches and contribute to better survival and quality of life for affected individuals.
The 2027 research funding cycle includes opportunities for independent investigators and researchers in mentored career-development positions.
The programme is particularly relevant to researchers working in cardiovascular science, physiology, biomedical research, clinical investigation and related disciplines.
The Letter of Intent deadline is November 10, 2026. Full proposals are by invitation only, with invited applications due February 2, 2027.
Key details
| Category | Details |
|---|---|
| Funding organization | Additional Ventures |
| Programme | Single Ventricle Research Fund (SVRF) |
| Funding cycle | 2027 awards |
| Independent Investigator Track | Up to US$600,000 in direct costs |
| Career Development Track | Up to US$300,000 in direct costs |
| Award duration | 3 years |
| Indirect costs | Up to 10% in addition to the direct-cost award |
| Research focus | Single ventricle heart disease and related complications |
| Eligible applicants | Doctoral-level principal investigators, including eligible independent investigators and mentored postdoctoral researchers |
| Letter of Intent deadline | November 10, 2026 |
| Full proposal deadline | February 2, 2027, by invitation only |
| Expected award announcement | By June 20, 2027 |
| Anticipated funding start | July 1, 2027 |
About Additional Ventures
Additional Ventures Research Grants 2027 | Up to US$600,000 for Single Ventricle Heart Disease Research
Additional Ventures is a nonprofit organization dedicated to addressing the critical gaps in understanding and treating single ventricle heart disease.
Its research funding programmes support scientific investigations intended to improve care, develop new therapeutic opportunities and address complications that affect long-term health.
The organization invests in research that can help explain the biological and physiological mechanisms underlying single ventricle heart disease.
Through the Single Ventricle Research Fund, Additional Ventures supports investigators conducting foundational research that could contribute to better treatment, prevention and management of complications.
The fund encourages innovative research approaches and interdisciplinary collaboration while emphasizing a clear connection between scientific discoveries and meaningful outcomes for people living with single ventricle heart disease.
About the Single Ventricle Research Fund
The Single Ventricle Research Fund is Additional Ventures’ flagship annual research award programme.
It supports foundational studies addressing single ventricle heart disease and the complications that contribute to long-term morbidity and mortality.
The programme aims to:
- Improve understanding of single ventricle heart disease.
- Investigate the mechanisms underlying long-term complications.
- Advance scientific knowledge that may support improved care.
- Encourage research that could lead to new therapeutic opportunities.
- Support investigators at different career stages.
- Promote innovative approaches to improving patient outcomes.
The sixth funding cycle welcomes proposals directly relevant to improving outcomes for individuals with single ventricle heart disease.
Research proposals should demonstrate how the proposed work could contribute to understanding, preventing or reversing complications associated with the condition.
Research funding available
Additional Ventures Research Grants 2027 | Up to US$600,000 for Single Ventricle Heart Disease Research
Additional Ventures offers two main tracks through the Single Ventricle Research Fund.
1. Independent Investigator Track – Up to US$600,000
The Independent Investigator Track provides funding for eligible investigators conducting foundational research relevant to single ventricle heart disease.
<text strong>Funding details</text>
- Award amount: Up to US$600,000 in direct costs.
- Award duration: Three years.
- Indirect costs: Up to 10% in addition to the direct-cost award.
- Applicant category: Independent investigators.
- Eligible career levels: Includes instructors, assistant professors and tenured faculty, as well as other qualifying independent investigators.
The track supports researchers with doctoral-level qualifications who are conducting independent research.
Collaborative proposals are encouraged. Multiple lead investigators may participate when they make significant contributions to the proposed project.
One principal investigator must be designated as the primary contact, with other eligible investigators listed as co-investigators.
Up to five co-investigators may be included on each project, subject to the programme’s eligibility requirements.
2. Career Development Track – Up to US$300,000
The Career Development Track supports researchers working in mentored positions who are developing their scientific careers.
<text strong>Funding details</text>
- Award amount: Up to US$300,000 in direct costs.
- Award duration: Three years.
- Indirect costs: Up to 10% in addition to the direct-cost award.
- Applicant category: Postdoctoral fellows or equivalent researchers.
- Career stage: Researchers holding mentored positions.
This track is designed to support the next generation of investigators working on important research questions related to single ventricle heart disease.
Applicants must meet the programme’s doctoral qualification and mentored-position requirements.
Collaborative proposals are not accepted through the Career Development Track.
Research areas supported
The 2027 Single Ventricle Research Fund welcomes foundational research aligned with Additional Ventures’ Research Roadmap.
The programme emphasizes research that can improve understanding of the mechanisms contributing to long-term complications and outcomes.
Domain I: Add back a pump
This research domain focuses on the biological and engineering principles required to restore or support circulatory function.
Potential research directions include:
Build a biological pump
Research investigating biological approaches and scientific mechanisms relevant to restoring or supporting circulatory function.
Build a mechanical ventricle
Foundational investigations into the biological, physiological or engineering principles needed to support circulatory function.
Projects must focus on foundational research.
Applications primarily focused on device design, prototype development, product optimization or precommercial testing are outside the scope of this award mechanism and may be more appropriate for another Additional Ventures funding programme.
Domain II: Address sequelae
The second research domain focuses on complications associated with single ventricle heart disease.
Additional Ventures is particularly interested in research that investigates the mechanisms underlying long-term morbidity and mortality.
Relevant areas include:
- Systemic circulatory regulation.
- Lymphatic and immune equilibrium.
- Liver health.
- Kidney and gut perfusion.
- Cardiac integrity and rhythm stability.
- Neurodevelopment.
Researchers may investigate how these complications develop, how they interact and how they could potentially be prevented or reversed.
Projects should clearly connect their research questions to long-term health, survival or quality of life.
Who can apply?
Additional Ventures Research Grants 2027 | Up to US$600,000 for Single Ventricle Heart Disease Research
The Single Ventricle Research Fund is intended for doctoral-level researchers conducting eligible foundational research.
Applicants must meet the programme’s qualifications and career-stage requirements.
Independent Investigator Track eligibility
Eligible applicants include independent investigators holding doctoral degrees, such as:
- PhD.
- MD.
- PsyD.
- Equivalent doctoral qualifications.
The track is open to independent investigators at different academic career levels, including instructors, assistant professors and tenured faculty.
Eligible investigators may submit collaborative proposals, provided all participating lead investigators meet the programme’s eligibility requirements.
Career Development Track eligibility
The Career Development Track is open to postdoctoral fellows or equivalent researchers holding mentored positions.
Applicants must have the appropriate doctoral qualification and meet the programme’s career-stage requirements.
Collaborative applications are not accepted under this track.
Institutional requirements
Researchers should consult the official programme guidelines to confirm that their institution and proposed project meet the funder’s requirements.
The programme supports research projects at qualifying research-based institutions.
Applicants should coordinate with their institution’s research administration or grants office before submitting an application.
What types of research are eligible?
Additional Ventures supports foundational research intended to improve understanding of single ventricle heart disease.
The proposed work should clearly demonstrate how its scientific aims relate to the mechanisms driving long-term morbidity and mortality.
Eligible research may investigate:
- Biological mechanisms of single ventricle heart disease.
- Physiological mechanisms affecting circulation.
- Organ-level complications.
- Interrelated multi-organ complications.
- Mechanisms associated with long-term health outcomes.
- Research that may inform prevention or reversal of complications.
- Scientific approaches that could contribute to improved treatment.
The programme welcomes innovative proposals that may introduce new concepts or unexpected research directions.
However, all proposals must maintain a clear connection to improving outcomes for individuals with single ventricle heart disease.
What research is not supported?
The Single Ventricle Research Fund is specifically designed to support foundational research.
The following types of projects are not considered within the programme’s scope:
- Registry construction.
- Biorepository development.
- Clinical trials.
- Projects without a clear connection to single ventricle heart disease outcomes.
- Research focused exclusively on cardiac development without a clear connection to long-term patient outcomes.
- Projects primarily focused on device design or prototype development.
- Product optimization or precommercial testing.
Additional Ventures has other funding mechanisms for certain translational and device-development projects.
Researchers should review the official programme guidance to determine whether their proposed work fits the Single Ventricle Research Fund or another funding opportunity.
Funding benefits
Successful applicants may receive financial support to conduct eligible research over a three-year period.
Depending on the selected track, funding may provide:
- Up to US$600,000 in direct research costs for Independent Investigators.
- Up to US$300,000 in direct research costs for Career Development applicants.
- Funding over three years.
- Indirect costs of up to 10% in addition to the direct-cost award.
- Support for foundational research into single ventricle heart disease.
- Opportunities to advance scientific understanding of long-term complications.
- Support for research that may contribute to improved care and therapeutic opportunities.
The maximum award amount is not guaranteed.
Applicants should prepare budgets consistent with the programme guidelines and the proposed research.
Application deadlines
The 2027 Single Ventricle Research Fund has the following schedule:
| Application stage | Deadline or timeline |
|---|---|
| Letter of Intent | November 10, 2026 |
| Full proposal invitation | By December 15, 2026 |
| Full proposal submission | February 2, 2027 |
| Award announcement | By June 20, 2027 |
| Anticipated funding start | July 1, 2027 |
The full proposal stage is invitation-only. Researchers must first submit a Letter of Intent and receive an invitation before submitting a full proposal.
Applicants should verify the current programme timeline and submission instructions on the official fund page.
How to apply for Additional Ventures Research Grants
Additional Ventures Research Grants 2027 | Up to US$600,000 for Single Ventricle Heart Disease Research
Researchers interested in the programme should follow the official application process.
Step 1: Review the official funding programme
Visit the Single Ventricle Research Fund page.
Read the programme description, research domains, eligibility requirements and application instructions.
Step 2: Review the Research Roadmap
Applicants should examine the Additional Ventures Research Roadmap and identify how their proposed project aligns with the programme’s research priorities.
The proposal should demonstrate a clear connection between the research question and improving outcomes for individuals with single ventricle heart disease.
Step 3: Select the appropriate track
Determine whether your project fits:
- Independent Investigator Track.
- Career Development Track.
Applicants should confirm that their qualifications and career stage meet the selected track’s requirements.
Step 4: Prepare the Letter of Intent
Prepare and submit the Letter of Intent according to the official programme instructions.
The Letter of Intent deadline is November 10, 2026.
Applicants should follow the current guidelines for the required content, submission format and application portal.
Step 5: Wait for the full proposal invitation
Additional Ventures plans to issue full proposal invitations by December 15, 2026.
Only invited applicants may proceed to the full proposal stage.
Step 6: Submit the full proposal
Invited applicants must submit their full proposals by February 2, 2027.
The application should follow the official requirements for research aims, methodology, budget, institutional information and other required materials.
Step 7: Await the award announcement
Additional Ventures Research Grants 2027 | Up to US$600,000 for Single Ventricle Heart Disease Research
Awardees are expected to be announced by June 20, 2027.
The anticipated funding start date is July 1, 2027.
Important application tips
1. Focus on single ventricle heart disease
The proposed research must be directly relevant to the programme’s scientific focus.
2. Demonstrate a meaningful research question
Explain the knowledge gap and how the proposed work could improve understanding of long-term complications.
3. Connect mechanisms to patient outcomes
The programme prioritizes research that can contribute to better survival, health and quality of life.
4. Choose the correct applicant track
Independent investigators and mentored postdoctoral researchers have different eligibility requirements.
5. Review the exclusions carefully
Clinical trials, registry builds, biorepository development and primarily device-development projects are not supported through this award mechanism.
6. Submit the Letter of Intent before the deadline
The full proposal stage is invitation-only, so applicants must complete the initial submission process.
7. Coordinate with your institution
Researchers should consult their grants administration office about institutional eligibility, budget preparation and submission requirements.
Frequently asked questions
How much funding is available?
The Independent Investigator Track offers up to US$600,000 in direct costs over three years.
The Career Development Track offers up to US$300,000 in direct costs over three years.
Indirect costs of up to 10% are provided in addition to the funded amount.
Is the grant open to international researchers?
The programme is presented as supporting eligible researchers at qualifying research-based institutions. Applicants should review the official guidelines for institutional and applicant eligibility.
Do not assume that every institution or country is automatically eligible.
Can postdoctoral fellows apply?
Yes. The Career Development Track is designed for postdoctoral fellows or equivalent researchers holding mentored positions who meet the programme’s doctoral qualification requirements.
Can independent investigators submit collaborative proposals?
Yes. Collaborative proposals are encouraged through the Independent Investigator Track, subject to the programme’s investigator eligibility requirements.
Collaborative proposals are not accepted through the Career Development Track.
Are full applications open to everyone?
No. The full proposal stage is invitation-only.
Applicants must submit a Letter of Intent and receive an invitation to submit a full proposal.
What is the deadline?
The Letter of Intent deadline is November 10, 2026.
Invited full proposals are due February 2, 2027.
What research areas are supported?
The fund supports foundational research relevant to single ventricle heart disease, including circulatory function, systemic regulation, lymphatic and immune equilibrium, liver health, kidney and gut perfusion, cardiac integrity, rhythm stability and neurodevelopment.
Does the grant support clinical trials?
No. Clinical trials are not considered under the Single Ventricle Research Fund.
The programme is focused on foundational research that improves mechanistic understanding of single ventricle heart disease.
Final thoughts
Additional Ventures Research Grants 2027 | Up to US$600,000 for Single Ventricle Heart Disease Research
Additional Ventures Research Grants 2027 | Up to US$600,000 for Single Ventricle Heart Disease Research. The Additional Ventures Single Ventricle Research Fund offers a significant research funding opportunity for eligible investigators working to improve understanding and outcomes in single ventricle heart disease.
With awards of up to US$600,000 for independent investigators and up to US$300,000 for researchers in mentored career-development positions, the programme supports foundational research over three years.
Researchers should carefully review the eligibility requirements, research domains and application process before preparing their submissions.
The Letter of Intent deadline is November 10, 2026. Full proposals are accepted by invitation only.
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